Background: The hospital nurse workforce is experiencing greater workloads resulting in shorter hospital stays, rising average patient acuity, fewer support resources, and a national nurse shortage. Higher nurse workloads are associated with burnout and job dissatisfaction. Patients have the right to expect quality of care. Patient satisfaction with nursing care is considered an important factor in explaining patients' perceptions of service quality. In pediatric settings, nurses have unique caring roles because of the vulnerable and intensive nature of their pediatric patients and the special bonds that can form especially when caring for patients and their mothers lasts for long periods of time. Aim: examines the relationship between nurses’ burnout and mothers' satisfaction with pediatric nursing care. Design: descriptive correlation design. Subjects: Convenient sample of 60 mothers and 55 nurses were involved in this study. The study was conducted at Pediatric Intensive Care unit (P.I.C.U). at Tanta University Hospital. Tools: Two tools were used in this study. An Interviewing Patient's Satisfaction Questionnaire (IPSQ) that was used to measure the patients' satisfaction regarding nursing care. The second tool was Maslach Burnout Inventory (MBI). Results: There was low level of nurses' personal accomplishment and high level of depersonalization and emotional exhaustion, mothers' dissatisfaction was also, found. There was statistical significant negative correlation between nurses' personal accomplishment (burnout) and mothers' satisfaction regarding needs and expectations. Reduced personal accomplishment, depersonalization, emotional exhaustion and inappropriate work condition are the factors that lead to nurses’ burnout. Patient dissatisfaction results from nurses' communication, meeting children's need and expectations with highest percent in nurses' skill and competences. Recommendation: Developing an educational program for pediatric nurses to improve their communication skills.