Background: Low back pain (LBP) appeared as one of the most critical problems between residents by its negative effect on life. We aimed in this research to measure the prevalence and determinants related to low back pain (LBP) between residents of the family medicine program in Makkah city, Saudi Arabia. Aim of the study: To assess the magnitude of low back pain and its risk factors to improve the family medicine resident's productivity and performance. Method and Material: This study was a cross-sectional study carried out between residents ofthe joint program of family medicine (JPFM) in Makkah city. Residents of different levels were randomly selected from the family medicine program, using a self- assessed questionnaire, which contained 37 items, the questionnaire was divided into three parts: demographic data, personal and occupational characteristics, and prevalence data. Results: This research results showed a prevalence of low back pain (LBP) and it was (76.4%). Investigated data of residents showed significance (P<0.05) tojob satisfaction, stress level, and prevention strategies. And showed non-significance (P > 0.05) to other dependents such as age, gender, smoking, stress level, and BMI. To relieve back pain many affected residents used painkillers and took rest as the best option. Conclusion: Results showed LBP has a high prevalence rate in family residents with many avoidable risk factors. Recommendation: This research further recommends that more studies, educational programs, and campaigns should be conducted to reduce the severity of the condition.