CERTIFICATE

IMPACT FACTOR 2021

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

The possible ameliorative effect of nigella sativa seeds against hyperlipidemia-induced injury in the cerebellar cortex of rats

Author: 
Rasha A. Alshali and Laila M. Aboul- Mahasen
Subject Area: 
Health Sciences
Abstract: 

Hyperlipidemia describes abnormally high levels of lipoproteins, cholesterol, triglycerides in the blood. It is contributed by high fat diet (HFD) rich in saturated fatty acids, sedentary lifestyle plus other factors. HFD induces biochemical alteration associated with structural changes in the frontal cerebral cortex and the cerebellum of rats. This study evaluated the possible protective effect of Nigella sativa (NS) seeds powder on the biochemical and histopathological changes induced by HFD in rat’s cerebellar cortex. It lasts 2 months and involved 24 rats separated into group I, control, group II, fed with HFD (20gm/100gm of diet/day), group III, fed with HFD plus treated with NS seeds powder (300mg/kg/day). After treatment, blood samples were collected for lipid profile assessment. Cerebelli were extracted and processed for histological examination. Body weight was increased in the hyperlipidemic group compared with the control group but reduced again by NS treatment. The serum lipid profile in hyperlipidemic rats showed significant improvement in rats fed on HFD with NS seeds powder. Microscopically, the cerebellar cortex of hyperlipidemic group showed marked degenerative changes in Purkinje cell layer with many swollen Bergmann cells. GFAP expression was abundant in the astrocytes of the three cortical layers. The cerebellar cortex of hyperlipidemia with NS-treated group showed marked improvement as most of the Purkinje cells had almost normal appearance and GFAP expression showed moderate expression as the control group. This study revealed significant biochemical results that are compatible to the histological and immunohistochemical findings. Thus, NS seeds had neuroprotective effects from hyperlipidemia-induced injury in the cerebellum.

PDF file: 

CALL FOR PAPERS

 

ONLINE PAYPAL PAYMENT

IJMCE RECOMMENDATION

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

EDITORIAL BOARD

CHUDE NKIRU PATRICIA
Nigeria
Dr. Swamy KRM
India
Dr. Abdul Hannan A.M.S
Saudi Arabia.
Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran