Coccinia grandis is a dioecious, perennial, and herbaceous climber, with glabrous stems,tuberous roots, and axillary tendrils. Leaves are alternate and simple. Fruit is a smooth, bright red, ovoid to ellipsoid berry 2.5–6 cm The present investigation was analyzed to evaluate the pharmacognostical studies on selected medicinal plant. The parameters such as anatomical, histochemical colour reactions, and phytochemical studies were done. The values calculated and data collected could be used for the identification of powdered drug of this taxon. Pharmacognostical analysis will help to identify authentically the drug from adulteration, substitution in the herbal market and also for the quality control in pharmaceutical industry.