It remains unknown whether successful H. Pylori eradication therapy leads to a relief of dyspepsia and subsequent arrest or reducing the acid suppressants use. Aim of the study is to assess H. Pylori eradication therapy and utilization of acid suppressant medications in patients with peptic ulcer disease. The eradication of helicobacter pylori is recommended for patients with peptic ulcer. In the present study out of 280 patients consulted 82 had H. Pylori positive result. Among these 60 patients undergone eradication therapy successfully. This result in the arrest of acid suppressant medication and attain complete cure during the follow up period. The remaining patients are still on maintenance therapy with acid suppressants. This study also finds out whether the use of acid suppressants is inappropriate and is prescribed for justified indication. Around 60% of patients is taking acid suppressant for non justified cases. This will lead to the long term use of medications and increases economic burden to the patients.