Nutritional psychiatry is a new area of research that seeks the relationship of nutrients in the brain axis and associated comorbidities. At the moment, there is an increasing discussion on the brain and heart axis seeking the understanding of the activity in reducing oxidative stress and mitochondrial respiratory chain, among the nutrients investigated is coenzyme Q10 (CoQ10). This important nutrient, which has a number of already established functions, has benefits in the treatment of psychiatric and heart disorders, it is believed to be the result of its antioxidant property and production of mitochondrial energy. However, there is a scarcity of studies on CoQ10 in the line of nutritional psychiatry, including there is still no consensus on the appropriate dosage or therapeutic plasmatic level of this nutrient. And this information is necessary both for the treatment of mitochondrial diseases and psychiatric and heart disorders. Therefore, this study seeks to describe the current knowledge about CoQ10 in the axis of nutritional psychiatry in the disordens brain and heart.