Non-steroidal anti-inflammatory drugs (NSAIDS) as donor Ligands in Organo-lanthanide derivatives: synthesis, spectroscopic analysis, thermal stability, high performance-liquid chromatographic studies and biological screening of Organo- lanthanide derivati

Non-steroidal anti inflammatory drugs can be used as donor ligands for complexations of rare earth metals. Amoxicillin is non-steroidal, anti inflammatory drug and is used as extended-spectrum also penicillin and clavulanic acid act as β-lactamase inhibitor. The active components of drugs were detected at 210nm wavelength with the UV detector. Some new organo Erbium (III), Lanthanum (III) and Gadolinium (lll) derivatives of non-steroidal anti inflammatory drugs were synthesized. These compounds were structurally characterized by elemental, molar conductivity, U.V visible and Fourier transform infra red analysis . Also high performance liquid chromatography and thermal gravimetric analysis shows the stability and presence of hydrated and coordinated water molecules by which enthalpies can be determined. The thermal degradation study shows the final product metal oxide. The compounds were also screened against different plant pathogens. The molar conductance values suggest the non electrolytic nature of metal complexes. Thermal behavior suggests their more ordered activated state in complex formation. Phenyl bonded silica HPLC column was used to separate metal-NSAIDS complexes. The aim of present study is to synthesize and characterized a number of organo lanthanide complexes with NSAIDs, based on the fact that newly synthesized compounds show significant activity against microbes. Their cytotoxicity data indicates their positive lethality.