CERTIFICATE

IMPACT FACTOR 2021

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Molecular modeling of angiotensin type 1 receptor for angiotensin receptor blockers

Author: 
Dr. Praveena, P., Amitava, Dr. Sudarsanam, D. Jayanthi
Subject Area: 
Life Sciences
Abstract: 

Diabetic nephropathy is characterized by progressive persistent proteinuria, hypertension, decline in renal function by decreasing glomerular filtration rate, and risk of cardiovascular disease. Recently, agents (ARBs) developed with antihypertensive and antiproteinuric efficacy that block the RAS by preventing angiotensin II from binding to its subtype1 (AT1) receptor, belong to the family of GPCRs. Hence efforts are to design the drug molecules to inhibition of angiotensin receptor blockers by using bioinformatics tools. SBDD confirms the angiotensin II binds to the AT1 receptor within the transmembrane domains in an extended conformation, and its C-terminal residue interacts with transmembrane domain VII at Phe-293/Asn-294.Methionine proximity assay, determine the molecular environment of this binding pocket (L112M and Y113M in TMD III; F249M, W253M, H256M, and T260M in TMD VI; and F293M, N294M, N295M, C296M, and L297M in TMD VII.). Based on information of Target protein id P30556 in Uniprot, Pubmed all and I-TASSER that allow to automatically generate high-quality predictions of 3D structure and biological function of protein molecules based on C-Score and TM-Score. SPICKER clustered simulated decoys and top five cluster centroids are selected for generating full atomic models. Target protein's ligand binding site was predicted by using both Q-Site Finder and Pocket Finder. Drug bank, clinical trials database was used for finding the drug molecule to blocking the angiotesin receptor type1 and drawing a ligand molecule in ACD/CHEMSKETCHI based on the ligand binding site and 2D-CORINA used in 2D to 3D convertions. Blind docking method dock the protein and small molecule at correct functional site. Based on Dock database calculation save the molecule in pdb format and view in PyMol and tools are used to finding the drug likeliness satisfying 5 Lipinski’s rules.

PDF file: 

CALL FOR PAPERS

 

ONLINE PAYPAL PAYMENT

IJMCE RECOMMENDATION

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

EDITORIAL BOARD

CHUDE NKIRU PATRICIA
Nigeria
Dr. Swamy KRM
India
Dr. Abdul Hannan A.M.S
Saudi Arabia.
Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran