Gallstone disease remains one of the most common medical conditions and leading cause of hospital admissions for gastrointestinal problems. The association between gallstone disease and metabolic syndrome has already been proved by previous studies. The aim of this study is to find out the relation between metabolic syndrome and gallstone disease and post operative complications after cholecystectomy in patients with gallstone diseases. We conducted a cross-sectional study among 100 patients with gall stone diseases during the period from october 2012 to September 2014 in the department of Surgery, Regional Institute of Medical Sciences Hospital, Imphal, Manipur, India. We found out that metabolic syndrome was associated with 36% gallstone disease and the patients with metabolic syndrome have higher chance of getting multiple, cholesterol stones and post operative wound infection compared to those who do not have metabolic syndrome. So we recommend that extra care should be given to patients with metabolic syndrome to prevent post operative wound infection or related complications.