The study was aimed at investigating the major challenges confronting the manufacturing sector, in particular master craftsmen. The study was carried out in the Tamale Metropolis. The target population was stratified into their trade areas such as mechanics, welders, electricians, blacksmiths, etc, and a total of 200 artisans were sampled using the simple random method. The results revealed that majority (97%) of the master craftsmen lack the requisite financial support to boost their firms irrespective of level of education and age in business. Rate of expansion of business was also slow as most of the respondents (69.7%) rated their businesses were slow in terms of growth. Lack of access to market was another major constraint to the master craftsmen. It was concluded that most Master Craftsmen lack financial support to enable them expand their businesses. In view of the increasing youth, as well as graduate unemployment, it is evident that the manufacturing sector is capable of absorbing most of the youth only if it is given the necessary attention it deserves. It was recommended that Master Craftsmen be given in-service training to enhance their technical and managerial skills. They should also be given financial support, irrespective of the size of the firm, to booze it.