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Insomnia and obesity: a complex neuroendocrine relation insomnia and obesity

Author:

Lígia Aurélio Bezerra Maranhão Mendonça, Natali Camposano Calças, João Pedro Teixeira Basmage, Larissa Sawaris Neto and José Carlos Souza

Subject Area:

Health Sciences

Abstract:

Insomnia is a sleep disorder of great magnitude that significantly interferes with the homeostasis of the circadian and sleep systems. This culminates in important changes in the leptin-ghrelin axis, leading to adverse effects on the dietary choices, a consequent increase in weight and installation of obesity. The hormonal and metabolic mechanisms that promote this important change are not yet fully understood. However, it is known that a chronic process of sleep deregulation culminates in increased levels of ghrelin and decreased levels of leptin, resulting in a vicious cycle. Therefore, it is necessary to raise the population's awareness for the importance of sleep periods in order to avoid metabolic imbalances involving the development of diseases, especially obesity.

PDF file:

25761.pdf

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