Indigenous plant source provide potential anti-inflammatory compounds

Alkaloids, from the natural sources are commonly used in medicine for their medicinal properties; agriculture in the form of pesticides based on their toxicity. They are present in natural sources, or biologically synthesized from amino acids. Alkaloid, quinoline; are extensively used for various purposes as preparation of dyes, production of specialty chemicals, and has derivatives which are used as therapeutic candidates. Quinoline derivatives are identified from an indigenous plant variety Toddalia aculeata obtained from Kolli hills, in central Tamil Nadu, Namakkal district of India. Using the compounds extracted from source, quinoline derivatives are obtained. Structural variations present and binding, are studied based on interaction with protein target. Comparison is done among commonly used anti-inflammatory, antibiotic drugs. The result was found to be comparable thermodynamically, based on the overall stability and intermolecular interactions, in complexes.