Fruit flies react to taste molecules in a way which is quite similar to humans and within the detection range of mammals. They are attracted to sugars, avoid bitter and toxic molecules, and adapt their consumption of acids and salts to their internal needs. In Drosophila adults, contact chemoreception is mediated through hair-like structures, called sensilla, located on the mouthparts, the legs, the wings margin, and the ovipositor. The behavior paradigms are relatively complicated, it is necessary to understand how the fundamental behavior is organized at neural level, before a full understanding of the complex behavior. In the present study Drosophila melanogaster has shows biased preference when facing sensory stimulations towards varied concentrations of tobacco.