Background: The aim of this study is to assess the quality of life of CABG and PTCA patients with co morbid condition . Methods: This study was a prospective, well-controlled, interventional study conducted in 120 patients over a period of 6 months in a tertiary care teaching hospital. Patient quality of life were assessed using MacNew Heart related QoL questionnaire. Results: In this study, commonly seen co-morbid condition is Type 2 DM (65%) and least condition is Epilepsy (3.3%). Some of the risk factors identified among patients were Type 2 DM, Hypertension, Dyslipidemia, Family History, Social habits and Obesity. The study showed significant improvement in quality of life (P <0.01). Conclusion: The present study was performed to get a comprehensive overview of the impact of pharmacist in improving the QOL of CABG and PTCA patients and managing the co-morbid condition hence reduces the chances of re-occlusion.