Hepatoprotective and antioxidative potential of allium sativum in the treatment of pulmonary tuberculosis under dots

The anti-tubercular drugs Isoniazid and Rifampicin, the first line drugs used for tuberculosis therapy are associated with severe hepatotoxicity in Indian patients as compared to United State. Data reported that the combination of INH and RIF treatment in pulmonary tuberculosis patients taking ATD enrolled under DOTS, results in development of oxidative stress which has been considered as the most important mechanism of hepatotoxicity which results increase of MDA level decrease in body antioxidant level. MDA level is more in contrast to that observed in the normal GpI (48.21±12.13 n mol TBARS/ml blood Vs 13.56±2.06) & after treatment decreased significantly (** p<0.001). GSH levels in INH+RIF treated GpII and caused significant decrease in the blood GSH as compared to Normal GpI (169.95±96.4 Vs 218.51±121.5) while after treatment level increases (** p<0.00) vs normal (GpI). Similarly trends were recorded in SOD and Catalase level after treatment respectably (**p<0.001) vs normal group (GpI) & ** p<0.001 vs normal group (GpI). The postulated role of garlic organosulphur compounds in the prevention of INH and RIF hepatotoxicity was explained by their ability in free radical scavenging and prevention of hepatocyte GSH depletion. The aim of the study was to assess the role of garlic supplementation in the hepatoprotection of INH and RIF induced hepatotoxicity in pulmonary tuberculosis by monitoring the antioxidant levels.