CERTIFICATE

IMPACT FACTOR 2021

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Genetic studies in type2 diabetes in unani concepts of temperament; association between pro12ala polymorphism of peroxisome proliferator-activated receptor-gamma 2 (PPAR-α) of Indian populati

Author: 
Seelamneni Thulasamma, Alokananda Chakraborty, Kaiser Jamil, Lahari Kuna, Shravan Ghali and Kazmi, M.H.
Subject Area: 
Life Sciences
Abstract: 

Background: Diabetes is a very common metabolic disorder among Indian population. This study validates some of the Unani concepts of humors or temperaments (Phenotypes), with regard to Type 2 Diabetes mellitus. We selected Damvi subjects for our study, with an aim to determine its association with the genetic biomarker- Peroxisome proliferator-activated receptor - Gamma (PPAR-γ) and other biochemical parameters. Methods: The Unani clinicians randomly selected 100 diabetic damvi patients who were attending the Unani hospital for treatment and 100 healthy volunteers belonging to damvi temperament. Institutional Ethics Committee approved the project. Besides looking at temperaments/ humors as susceptibility factors – we included a genetic factor-PPAR-γ to our investigation. We have genotyped the Proline 12 alanine (Pro12Ala C➝G) gene polymorphism by PCR-RFLP. Results: We found more of CC genotypes in both cases and controls and less number of the hetero genotypes CG in cases compared to controls. Interestingly the homo genotypes GG were not found in this group of patients as well as controls. In our study we observed a significant increase (p<0.001) in malondialdehyde (MDA) levels and GST levels using enzyme-linked immunosorbent assay (ELISA). We also found that plasma glucose levels (fasting and postprandial), total cholesterol, triglycerides, liver function tests and renal function tests were very high using Erba Autoanalyzer. Conclusion: We found that Damvi temperaments (Sanguine- Phenotypes) were more prone to T2DM; hence it is important that damvi phenotypes could be counseled to take preventive measures, also PPAR-γ and antioxidant levels have been identified as biomarkers for T2DM.

PDF file: 

CALL FOR PAPERS

 

ONLINE PAYPAL PAYMENT

IJMCE RECOMMENDATION

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

EDITORIAL BOARD

CHUDE NKIRU PATRICIA
Nigeria
Dr. Swamy KRM
India
Dr. Abdul Hannan A.M.S
Saudi Arabia.
Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran