Formulation and evaluation of triple layered matrix tablet of aceclofenac using gum accacia as core material

The aim of present work was to develop once daily sustained release matrix tablet of aceclofenac by wet granulation technique using gum acacia. Aceclofenac sodium being the newer derivative of diclofenac having short biological half life (4hrs.), so it require more than one dose per day to maintain therapeutic dose. Total four formulations of aceclofenac matrix tablet were prepared using different concentration of gum acacia and evaluated for various parameters like weight variation, hardness, swelling index, friability, percent drug release and various release profile like zero order, first order, higuchi's, and koshemeyrs-peppas studied. All the evaluation parameters met pharmacopeial specifications and through dissolution studies it was concluded that MTX1showed height percent drug release and MTX4 showed lowest percent drug release at the end of 8 hrs. Matrix tablet of aceclofenac was successfully prepared and evaluated and it can be concluded that matrix tablet prepared with gum acacia showed release rate for a prolonged time and can be of great importance for “once daily” tablet to reduce side effects and toxicity related with NSAIDs.