Objective: This research aimed to appraise and synthesis existing literature on using the “flipped learning approach in nursing education and its impact on students in the Saudi Arabia context. Design: The systematic review method was finalized from three different databases July 2019: PubMed, Psyc INFO, and Google Scholar, which contribute to the achieving of various objectives. The methodological quality of included studies was assessed with the criteria established by Buckley et al., 2009. Results: The studies reviewed indicate that there is a potential impact of applying a flipped learning approach in nursing education, where it has been shown to achieve several outcomes, in addition to having several psychological effects on students that may sometimes be positive and at other times negative. Conclusion: The study results suggest that the flipped learning approach can improve students' awareness, knowledge, academic achievement, interaction, participation, and collaboration. However, studies also indicate the need to create a stimulating and enjoyable learning environment for students by identifying their preferred learning patterns.