This paper is based on a study to identify the type of media resources used in instruction and to examine the factors influencing the use of media resources in the School of Public Health at Moi University. Survey research design was employed in order to cover the study population of all the lecturers and students. Therefore, 24 lecturers and 213 students were chosen, making a total of 237 respondents. Convenient sampling technique was used to select key informants. Data were collected using questionnaire, interview schedule and observation checklist. The data collected was coded accordingly and analyzed using the Statistical Package for Social Science (SPSS v. 12). The results were presented using descriptive statistics. The findings showed that technological factors, individual factors and organizational factors influenced the use of media resources. Based on these findings, the study recommended that the School formulates sound procedures which would guide the procurement, use, maintenance of Media resources, as well as establish an instructional Media Centre. Further research should also be done before adoption of media resources and on e-learning, plus streaming the Media in the School of Public health.