Introduction: Patients who undergo orthodontic therapy also have changes in their oral ecologic, such as a low-pH environment, increased retentive sites for Streptococcus mutans, preventive strategies should be independent of patient cooperation, and the drug should be released over a prolonged period of time. Hence incorporation of antibacterial agents in orthodontic adhesivess provide desired results. Aims and objectives: To assess the antimicrobial properties of orthodontic composite resin when combined with various antimicrobial agents and their effect on the mechanical properties of the composite material along with the evaluation of the release of anti-microbial agents from the modified composite. Material and Methods: 100 extracted premolars divided into 4 groups (25each)and each group was bonded with composite adhesive mixed with respective anti-microbial agent Benzalkonium Chloride 0.1% (w/w) ,Chlorhexidine 0.2% (w/w) and Triclosan :0.3% (w/w)The statistical analysis was done using IBM SPSS (Statistical package for social sciences) software (Version 21.0). Conclusion: Benzalkonium chloride modified adhesive showed better dependability and clinical reliability as compared to Triclosan modified orthodontic adhesive group and Chlorhexidine modified orthodontic adhesive group.
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