An ethno-medico-botanical field survey was conducted during from 2013-2014 for document the medicinal plants used by traditional herbal healers in Harappanahalli taluk of Davangere district, Karnataka state, India. The information about plants species and their local names, part used, mode of drugs preparation, dosage and duration were collected from 27 herbal practitioners and knowledgeable elder people residing in 16 randomly selected villages using semi-structured and questionnaire based interview. The present study indicated that 45 plant species belonging to 35 families by folk practitioners to treat various common to chronic human and veterinary ailments. Leaves exhibited the most frequently used plant part for the preparation of medicine.