Knowledge of root canal anatomy and their variation, straight line access to apical terminus, thorough cleaning and shaping with three dimensional obturation of root canals system are the keys to successful and predictive endodontics. Anatomical variations are more frequent in maxillary first molars in the form of additional canal, C-shaped canal configuration or fused roots but variation such as occurrence of Type I canal configuration is very rare in maxillary first molar. This article describes a patient with non-syndromic true generalized microdontia with endodontically involved single rooted permanent maxillary first molar having Type I root canal configuration managed successfully using cone beam computed tomography (CBCT) as a diagnostic tool.