Effect of thyroid hormone disorder on diabetes mellitus and hypertension

The present work was conducted at the diabetic and hypertention patients that have thyroid disorder. Fifty- diabetic and hypertention patients that have thyroid disorder from three hospitals in Hail, KSA were consecutively selected. Diabetic patients have a higher prevalence of thyroid disorders than the general population, this may influence diabetic management. In this study, we investigated thyroid hormone levels in diabetic and hypertention patients. The subjects in all groups were above 60 years of age. The concentration of thyroid stimulating hormone (TSH), free triiodothyronine (T3) and thyroxine (T4) were evaluated using a Microparticle Enzyme Immunoassay (MEIA) procedure. Patients with type 2 diabetes had significantly lower serum T3 levels (p=0.000). There were no significant differences observed in serum T4 (p=0.339) and TSH (p=0.216) levels between the all subjects. All the diabetic patients had high fasting blood glucose levels. The effect of diabetic and hypertention patients that have thyroid disorder on blood glucose showed that high significant increase on blood glucose with increasing aging. On the other hand there were a significant increase on fasting blood glucose in the population that increase in aging than young one. The liver enzymes AST, ALT and ALP were a significant increase in blood of human in the population that increases in aging and diabetic and hypertention patients that have thyroid disorder than young one. Concerning lipid profile, we noted that variety induced high significant variation of different lipid parameters in the population that increase in aging and diabetic and hypertention patients that have thyroid disorder. Results generally showed that increase in aging and diabetic and hypertention patients that have thyroid disorder were always high significant increase in their blood glucose and fasting blood glucose. Also, there is high significant increase in liver functions in the population that increase in aging and diabetic and hypertention patients that have thyroid disorder than young one and high significant variation of different lipid parameters in the population that increase in aging and diabetic and hypertention patients that have thyroid disorder than young one. We conclude that T3 levels were altered in the diabetic and hypertention patients that have thyroid disorder.