Aims and Objective: To determine the Effect of different denture adhesives on the retention of maxillary complete denture. Materials and Methods: Twenty edentulous patients were selected from department of prosthodontics and crown &bridge, Hazaribagh college of dental sciences. The sample consisted of 12 males and 8 females, the age range between (40-78) years. Measurement of the Retention For purpose of this study retention has been expressed in terms of the force required to dislodge vertically a maxillary complete denture using loading apparatus. The three denture adhesives used in this study were Super corega powder, Boots denture adhesive powder (Boots Company PLC. Nottigham, England), Lacalut Dent. Gel (paste) (Arcam GmbH Germany). At the first day of testing, retention of the maxillary denture was first recorded 15 minutes after insertion without the use of any denture adhesives. Measurements were repeated in the same manner, 15 minutes after the adhesive was applied (base line) and at 1 and 2 hours after first measurement with denture adhesive. After that the denture was removed carefully, cleaned and kept in water. All these measurements were repeated in the next day using a second type of adhesive and at the third day using the third type of adhesive. After finishing with the measurements, the metal bar was removed and the maxillary denture was polished and returned to the patient. Results: The result showed no statistically significant difference between powder and paste denture adhesive, and between vegetable gum and synthetic polymer denture adhesive at different time intervals (P>0.05). Analysis of variance was used to make comparison at time interval between the three denture adhesives. The result showed that the denture adhesives had a statistically similar effectiveness at each time interval.