Curcumin loaded hap@sio2 core-shell nps as a carrier for targeted drug delivery in the treatment of cancer

We are developed the targeted drug delivery by HAp@SiO2 core-shell NPs. Hydroxyapatite (HAp) core was prepared by wet chemical co-precipitation method using different chemical precursors and silica shell coated on the HAp nanoparticle by stober’s process. Polyethylene glycol and biotin was functionalized with HAp@SiO2 core-shell NPs via covalent linkage. curcumin was loaded onto the surface of HAp@SiO2 core-shell NPs by the electrostatic interaction between curcumin molecules and the polymer segment. HAp@SiO2 core-shell NPs was characterized by UV-visible, XRD, HR-TEM, and the polyethylene glycol (PEG), biotin conjugation was confirmed by FT-IR techniques. The drug release behaviour of HAp@SiO2-PEG-biotin NPs was investigated at different pH condition (PBS, pH-7.4 and 6.0).The cytotoxicity of the core-shell NPs against MCF-7(receptor-positive) and NIH-3T3 (receptor-negative) cell lines was assessed using the MTT assay. The results showed that curcumin loaded NPs increased cytotoxicity effect in MCF-7 than NIH-3T3 cell line. The overall results shown that the biocompatible HAp@SiO2 core-shell NPs may be a suitable nanocarrier for targeted drug delivery system.