A cross sectional study to evaluate diagnostic role of vaginal fluid creatinine in premature rupture of membranes in the department of obstetrics and gynaecology at s.m.s. medical college, Jaipur

Aims and Objective: To evaluate the diagnostic role of vaginal fluid creatinine in PROM (premature rupture of membranes) and find out appropriate cut off value of vaginal fluid creatinine levels to predict PROM. Materials and Methods: It was a cross-sectional study including two groups with 50 women in each group. Group I included confirmed PROM and controls were included in Group II. Vaginal fluid sampling was done and creatinine levels were assessed in both groups. Data analysis was done by Student’s t-test, Receiving operator characteristic curve and chi square test. Results: The mean value of vaginal fluid creatinine (mg/dL) was higher in the PROM group than the control group (0.75±0.16 and 0.19±0.06 respectively). The best cut-off point for vaginal fluid creatinine for diagnosis of PROM was >0.34mg/dL, with 100% sensitivity, 100% specificity, 100% PPV and 96% NPV (P=0.001). Conclusion: Vaginal fluid creatinine is a simple, practical, cost-effective and easily accessible test and its incorporation in the low resource setting will be a game changer in the diagnosis of PROM.