Background: Selection of Anterior teeth of complete Denture is selected based on curve distance (CD) of wax rim, but is there any correlation between curve distance (CD) and Combined Width (CW) Values for selection of denture teeth depending upon gender of the patient. Objective: The purpose of this study was to investigate whether the curve distance between the distal surfaces of maxillary canines (CD) is related to the combined width of the 6 anterior teeth (CW) when clinicians select denture teeth for patients depending upon the gender of the patients. The null hypothesis tested was that CD and CW measurements would not be correlated in male and female patients. Methods: One Hundred and Sixty dentate patients were selected in this study (80 male, 80 female), age ranges from 18-25 years old.The impression of the maxillary arches was made with irreversible hydrocolloid (chromatic alginate impression material, Tropicalgin, Zhermack) and poured in Type IV stone (Kalrock, kalabhai, Class IV dental stone). The width of each maxillary anterior tooth and the curve distance was measured on the casts at the widest surfaces of the tooth with a digital sliding caliper (Zhart Digital Vernier Caliper).The normality of numerical data was checked using the Shapiro-Wilk test. Result: CD and CW values was higher in males as compared to females. From the linear correlation measurement between CD and CW values, the linear regression equation obtained for male (CD = 7.271 + 1.056 × CW) and Female (CD = 6.701 + 0.935 x CW). Conclusion: The curve distance between distal surfaces of the maxillary canines can be accurately related to the combined width of 6 anterior teeth when selecting the denture teeth for either male or female patients.