Coronary artery disease is still one of the leading causes of death around the globe even though the mortality is on the decrease since 1970 in most of the industrialized countries. This marked reduction in coronary artery disease was largely driven by the significance of advancement in the novel treatment modalities used in these western countries. These strategies have ranged from advanced diagnostic modalities to various novel treatment methods. This article will review the recent advancement in the treatment of Coronary artery disease in respect to therapeutics and diagnostic modalities.