Objective: The aim of the present study is to evaluate the efficiency of microabrasion, enamel remineralising agent and resin infiltration technique in treatment of white spot lesion. Materials and Methods: Ninety extracted teeth with no visible enamel defects were taken. The teeth were then subjected to demineralisation cycle for 2 weeks. The samples after demineralisation were divided into three groups of thirty teeth each: GROUP A treated with microabrasion technique, Group B s treated with remineralising agent, Group C treated with resin infiltration technique. The microhardness, transmittance and absorbance values were recorded pre-treatment (T0), after demineralisation (T1) and after different treatment modalities (T3) using microhardness tester, and UV-Visible spectrophotometer respectively. The data were analysed using ANOVA followed by Bonferroni post hoc analysis to compare the microhardness and absorbance and transmittance between the groups. Results: The results suggested that there was statistically significant difference between group A, B,C in improvement of microhardness, transmittance and absorbance values after demineralisation, the improvement was more in group C followed by group A and group B. Conclusion: The results of the present concludes that white spot lesion can be best treated by resin infiltration technique which improves the microhardness as well as mask the white spot lesion lesions by getting camouflaged with the adjacent sound enamel.