Objective: The objective of this study was to compare the sorption of heat-cure and self-cure acrylic resins in different solutions. Materials and Methods: Two groups of material are used with the samples of self cure and heat cure. Two square shaped specimens with dimension of (20 mm × 20 mm × 2 mm) were prepared for each acrylic resin (heat cure and self cure) and then immersed in three solutions like distilled water, denture cleansing solution, combination of distilled water, and denture cleaning solution for 12 h alternatively at room temperature, and tested sorption by weight gain/loss method, respectively, after 1, 7, and 14 days. The data were analyzed by one-way analysis of variance followed by post hoc Tukey's test. Results: The mean value of self cure and heat cure in distilled water is about to be weigh by electronic weighing machine. These values were statistically significant. Overall, analysis of results showed the maximum sorption value in denture cleansing solution followed by alternative soaking in distilled water and combination of both. Least sorption was observed with distilled water followed by combination of both. Conclusion: Both heat-cure and self-cure acrylic resins showed varying water sorption in different solution. Denture cleansing solution is a better storage medium than distilled water and combination of both of heat-cure and self-cure acrylic resins.