Deficiencies in collaboration between healthcare professionals have a negative relation to the provision of healthcare and on patient outcomes. Collaborative practice has been shown to benefit civilian health care facilities by decreasing costs and increased patient, family, nurse, and physician satisfaction. This study aimed to investigate the levels of the collaboration between physicians and nurses and determine its relation to patient's satisfaction. Design: This study demonstrated a descriptive cross-sectional design. Setting: the study was carried out in Clinical Oncology Hospital, Menofiya University, Egypt. Subjects: Three groups of subjects included all staff nurses and physicians available at the time of the study, the third group was patients available at the time of the study. Tool: three tools were used; tool 1: Nurse–Physician Collaboration Scale. Tool II: Patient Satisfaction Questionnaire about nursing care .Tool III: Patient Satisfaction Questionnaire about Doctors. Results: Indicated that 94% of patients showed of high satisfaction about doctor, 66% showed high satisfaction for nurses' practice. When collaboration between doctors and nurses increase, the patients’ satisfaction increases. Conclusion: This study concluded that there was a positive relation to between collaboration among nurses and physicians and patient satisfaction. Recommendations: As nurse and physicians, it is essential that we should understand and tolerate our differences and foster our mutual interest in caring for patient better than ever.