Dental caries which is a pandemic disease can be prevented even before its occurrence. There are many ways in which it can be prevented either by removing the etiological factors or bringing the etiological factors under control. Recent findings have indicated that antimicrobials are quite useful in reducing the load of microorganisms which are responsible for caries. Chlorhexidine is one of the commonly used antimicrobial available in the market. However, there is a lack of consensus on evidence-based treatment protocols and controversy regarding the role of chlorhexidine in caries prevention among dental educator. So, this article summarizes about role of chlorhexidine in caries prevention.