This article deals with the USA’s doctrinal policy in the Caucasus and with the major developments in this concept. It states that, American foreign policy of Caucasus has always been loyal and truthful to peace and democracy, to prevention of threats against its allies. Starting from the period of “Monroe Doctrine” in the twentieth century up to Donald Trump’s current presidency term, the entire period is a subject of these analyses. The research paper also illustrates the changing priorities in American foreign policy towards the region of CIS countries and Caucasus, where the exploration and transition of energy resources from these regions occupy special place in the significance of the historical developments. The research states that, relations of NATO and Caucasian countries, reduction of Russia’s political, economic and military impact, restricting Iran’s and China’s regional activities and participations are also the effective measures for protecting the security of the States and its allies. It specifically pays attention to the issues related to the development of political and military chronicles around Armenia-Azerbaijan-Nogorno Karabakh conflicts. The paper brings a lot citations from the outstanding world political figures and political analysts, illustrates the commonalities and differences of socio-political line pursued by American foreign policy in various periods of presidency.