Cadmium induced bioaccumulation and oxidative stress in liver and kidney of male albino rat

The present study was carried out to know the cadmium (Cd) induced bioaccumulation and oxidative stress in liver and kidney of Cd treated rats. Wistar strain male albino rats were treated with cadmium chloride (CdCl2) at a dose of 1/10th LD50 / 48h i.e. 22.5 mg/kg body weight for 7, 15 and 30 days (d) long sojourn. After the specific time intervals, rats were decapitated and tissues like liver and kidney were isolated for the analysis of Cd bioaccumulation and assay of oxidative stress enzymes such as catalase (CAT), superoxide dismutase (SOD), glutathione -S‑transferase (GST) and glutathione peroxidase (GPx). Simultaneously lipid peroxidation (LPO) levels were also measured. There was a significant elevation in Cd bioaccumulation in both the test tissues with increased period of Cd treatment. Maximum Cd accumulation wasfound in 30d Cd treated rat kidney. A significant elevation in LPO levels with decreased activity levels of CAT, SOD, GPx, and GST were observed during Cd intoxication. Our study clearly reveals that Cd intoxication can disturb the antioxidant defense system and increase the body burden of Cd in the tissues.