This study aimed at investigating the availability and adequacy of science teaching/learning resources in public secondary schools in Bukoba District Council (BDC), Tanzania. Researchers considered that availability and adequacy of such resources in public secondary schools was a prerequisite for the implementation of compulsory science curriculum in BDC. The study used convergent parallel mixed method research design. The qualitative part employed phenomenology while the quantitate part used cross-sectional design. The target population involved heads of schools, heads of science department (HoDs), science teachers, students; also, included were parents and a District Education Officer for Secondary Schools (DEOSS). Data were collected using questionnaires, interview guide, and observation schedule. D escriptive statistics such tables and charts were used to analyse quantitative data. Qualitative data were organized into themes and presented in narrative form and direct quotes. The findings indicated that public secondary schools encounter various challenges that negatively affect the implementation of science curriculum. The study concludes that a few teaching/learning resources were adequately available as there were also inadequacy of most of the science teaching/learning materials in some of the public Secondary schools in BDC. The study recommends that School Principals must be fully involved in the budgeting process so as to express concrete estimates which reflect the actual needs of their schools. The Government and the Schools’ Management should as quickly as possible address those challenges for effective implementation of science curriculum.