Attenuation of haemodynamic response to laryngoscopy and intubation with lignocaine and nalbuphine: a comparative study

Background: Previous studies done on Lignocaine and Nalbuphine individually found to attenuate the haemodynamic stress response but none of the study compared the two drugs. To compare the efficacy of intravenous Lignocaine versus intravenous Nalbuphine for attenuating the stress response to laryngoscopy and endotracheal intubation. Material and method: The present study was a hospital based prospective, randomized study conducted amongst adults aged 20 years to 60 years who were scheduled for elective surgery under general anaesthesia in the Department Of Anaesthesiology And CriticalCare. The patients were randomly allocated to GROUP L (n = 30) Patients received intravenous lignocaine 1.5 mg kg-1 ninety seconds before tracheal intubation and GROUP N (n =30) received intravenous nalbuphine 0.2 mg kg-1 one hundred and twenty seconds before tracheal intubation. Results: All the patients were monitored for heart rate, blood pressure(systolic, diastolic and mean BP) for haemodynamic responses during laryngoscopy, endotracheal intubation or side effects in the postoperative period. There was no statistically significant difference between both groups with regards to mean age and gender. The attenuation of pressor response to laryngoscopy and endotracheal intubation was significantly better with nalbuphine as compared to lignocaine.There was no side effect in both the groups. Conclusion: It is safe to assume that the dosage of 0.2 mg/kg of Nalbuphine is better at the attenuation of haemodynamic pressor response to laryngoscopy and endotracheal intubation than Lignocaine 1.5 mg kg -1.