Background: Wheezing is considered as an important sign for bronchial hyper-responsiveness in children and adults, and it is considered one of the most common causes for visiting the emergency room. Objective: to describe the prevalence of wheezing and its associated factors in four to six-year-old children living in Jeddah city. Methods: A cross sectional study was conducted in Jeddah city among four to six-year-old children who attend preschool between November to December 2018. We used an adapted and modified questionnaire filled by the parents; It was tested in a pilot study. Results: Out of 400 questionnaires sent to the parent n = 300 (75%) were retained to the researcher. Meanwhile, a highly significant result was observed (p <0.05) between wheezing and smoking in the family, home incense and coal use and low socioeconomic class. Conclusion: There is a significant association between presence of smoker at home, lower Family income and using of incense fragrant and coal inside the house and the appearance of wheezing in children born to atopic parents.