Introduction: Renal calculi is one of the most common disorders among urological diseases. Renal stone formation is a multifactorial condition. Objectives: To assess the knowledge on risk factors of renal calculi among female students and to determine the association between level of knowledge on risk factors of renal calculi with selected demographic variables. Methodology: Quantitative cross sectional research design was used and 300 female engineering students were selected by using systematic random sampling technique. Informed consent was taken from all the participants. Data was collected using a self- structured questionnaire. Results: Majority 227 (75.7%) of participants having inadequate knowledge, 39 (13%) of participants having moderate knowledge and only 34 (11.3%) of participants having adequate knowledge on risk factors of renal calculi. The associations of demographic variables with the level of knowledge on prostate cancer were determined by using chi-square test which revealed that, age, education of father, education of mother, occupation of father, occupation of mother, monthly family income, type of residence, type of diet, frequency of intake of non vegetarian diet, family history are statistically significant at p<0.01 level. Conclusion: The study concluded that majority of female engineering students had inadequate knowledge on risk factors of renal calculi. Hence there is a need to improve the knowledge regarding risk factors and preventive measures of renal calculi.