Present study was conducted to evaluate and compare the antimicrobial activity of Bougainvillea variegata leaves extract with Bougainvillea spectabillis leaves extract. Antibacterial activity of Methanolic and Ethanolic extract of these plant leaves were tested against Gram positive and Gram negative bacterial strains by observing the zone of inhibition. Antibacterial activity was done by disc diffusion method at a concentration of 500 µg/disc of the extract, using Ampicillin (Amp), Tetracycline (TE), Neomycin (N), Gentamycin (CN), Chloramphenicol (C), Ciprofloxacin (CIP), Erythromycin (E) as the standard. The bacterial strains used in the study were Staphylococcus aureus, Escherichia coli, Salmonella typhimurium, Enterococcus faecalis, Pseudomonas aeruginosa, Bacillus subtillis and Listeria monocytogenes . Both Methanolic & Ethanolic extracts have shown activity against Gram positive and negative bacteria. Extracts were not effective against Enterococcus faecalis.