Folk literature in field of Plants medicine is still barrel field of scientific investigations and finding. The currect work based on such ethnomedicinal plant like Butea monosperma (Lam.) Taub., Cleome viscosa L., Moringa oleifera L. and Sesbania grandiflora (L.) Poirfor its anti-inflammatory activity in different solvent system. It was find out that all four plants showing positive results were slight fluctuations according to solvent system used for plant extract. All results are recorded after 0.5, 1.0, 2.0 and 5.0 hrs. of treatment. Anti-inflammatory study form plant folk literature is still needs to analyzed which will be more beneficial for humankinds.