Anti-diabetic and antioxidant activity of betula hippolytii and betula platyphilla

Birch leaves were used as a substitute for birch bark, buds, and Chaga of birch. In traditional medicine, birch leaves are considered to have less toxic. Numerous researches conducted in Russia, Bulgaria, Japan, and China on Betula pubescens Ehrh., Betula pendula Roth., Betula rezniczenkoana (Litv.) Schischk., Betula humilis Schrank., Betula mandshurica (Regel) Nakai found that birch barks and leaves contain antioxidants, and they have anti-cancer, anti-yeast, antibacterial and anti-inflammatory properties, protect the liver and promote bile secretion. The studies showed that the medicinal plants had anti-inflammatory on stomach inflammation during extreme stress and promoted bile secretion. The birch leaf Phyto preparations used in experimental animals reduced insulin resistance of peripheral tissues and lowered blood glucose. It was noted in Traditional Mongolian Medicine that the birch bark was used to treat inflammation for acute diseases. The aim of this study was to determine the effect of two species of birch leaves on blood glucose and antioxidant activities in diabetic rats. The study was conducted at the Drug Research Institute of the Monos Group. 40 WISTAR non-linear white rats weighing 150-204 g, dry extract of birch leaves of the two species (Alloxan monohydrate Tokyo Chemical Industry LTD), IGM-100 3A blood glucose meter (Blood glucose test meter, Infopia LTD, Brussels Belgium), glucose test (Blood glucose test strip only), antioxidant activity kit (Rat Malondialchehyche Elisa KIT, cat. № EKRAT- 0266, Jilin province, China). The blood glucose level of the pathological control group rats reduced from 31.5 mmol/l to 17.1 mmol/l in 14 days. The blood glucose levels of Betula platyphylla group lowered to 6.3 mmol/l; Betula hippolytii group’s lowered to 6.9 mmol /l. The results showed that the maximum MDA level was determined from the control group, Betula hippolytii and Betula platyphilla groups. The maximum MDA rate was reduced by 33.9% and 53.5%, respectively for Betula hippolytii and Betula platyphilla groups. Betula hippolytii birch leaves and Betula platyphilla birch leaves have been shown to lower blood glucose levels and have antioxidant activity for diabetic animals.