Aggressive central giant cell granuloma- case report and review

Central giant cell granuloma (CGCG) is a benign intraosseous lesion predominantly involving the mandible in young females. Exact etiology of this lesion is controversial and remains unknown. However, three competing theories are prevailing which states that it could be a reactive lesion, a developmental anomaly or a benign neoplasm. CGCG has been grouped into non-aggressive and aggressive variants on the basis of clinical, radiographic and histopathologic features. This paper reported a case of 29 year old female patient, presented with complain of pain and swelling in right vestibule region for one and half month. Based on clinicoradiologic findings, provisional diagnosis of aggressive CGCG was given and the lesion was surgically intervened. Histopathological report revealed central giant cell granuloma. The healing was uneventful and no complication noted till date. The purpose of this article is to review the clinical, radiological, histopathological features and management of aggressive CGCG and highlight the importance of early diagnosis in management of aggressive CGCG.