Platelet rich fibrin: the potential regenerative biofuel in dentistry

Regulation of inflammation and increasing healing are the great challenges faced in clinical research and surgical denstistry. The use of platelet‑rich fibrin (PRF) is one of the promising innovations in the field of surgical dentistry. Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates having simple process of preparation without biochemical blood handling. It accelerates the healing mechanism of the tissue and reduces the inflammation. Platelet-rich-fibrin (PRF) is one such material that holds on to these growth factors enmeshed in the fibrin network which results in their sustained release over a period of time. This slowly releasing property of platelet can accelerate the wound healing process. It can be used alone or as an additive with other biomaterials. Thus PRF has emerged as one of the promising regenerative biomaterials in the field of dentistry. This article serves as an introduction to the PRF, its preparation and its potential clinical applications with emphasis on regeneration and wound healing.