This paper aimed at determining the factors influencing entrepreneurship performance in Tanzania with a specific reference to Kinondoni Municipality. The study was guided by the following objectives; examining the government policies which must be adopted to improve entrepreneurship performance; and assessing whether the existing government policies have capability to enhance Small and Medium entrepreneurship (SME) in Tanzania. The study adopted a case study methodology. A total of 30 respondents were drawn from different entrepreneurs who are dealing with small and medium businesses. The stratified sampling technique was employed in selecting the respondents. The study population was stratified according to gender and type of business owned. Data was analyzed through SPSS ver.20 and Microsoft excel statistical tools. The study found out that the factors which inhibit entrepreneurial performance include marketing, capital and premises; furthermore, existing government policies were also viewed by research respondents as double –edged instrument characterized as being both a facilitator and inhibitor/bottleneck of entrepreneurial performance. The study concludes that these constraining factors need to be reviewed and re-addressed by government through re-formulated and reviewed government policy frameworks so as to improve and foster entrepreneurial performance in this nation. The study therefore recommends a sound and prudent policy framework should be put in place in order to serve as a reliably authentic instrument to guide, unleash and provide for sustainable market, capital acquisition and premises; in this regard, the policy frameworks should be able to provide congenial or conducive business environment and significantly facilitate strategically reliable and productive responses to financing needs, entrepreneurial education and training, capital needs, simplification and easing of business working environment including registration procedures which in turn serves as a key catalyst and incentive factor to entrepreneurship moves and significant new ventures start up in Tanzania economy