Nowadays, Diabetes is a chronic metabolic disorder of the endocrine system. Type 2 diabetes is a major non-communicable disease with increasing prevalence at global level and for this it should be properly managed otherwise it can lead to a number of serious health issues including heart disease, stroke, kidney disease and peripheral vasculardiseases. Aim: The purpose of this study is to compare glycemic control with lifestyle modification, oral hypoglycemic and natural herbs in patients with type 2 diabetes mellitus. Method: Data from January 2018 to May 2018 Medicare Cardiac & General Hospital,Jinnah Medical college Hospital(Korangi campus) was used for this investigation. Questionnaire method of 102 patients is used to compare glycemic control with lifestyle modification and oral hypoglycemic drugs. Result: The study done on type 2 diabetes mellitus patients having increased BMI, fasting and Radom blood sugar and HBAIc above 6. Showed that oral hypoglycemic (metformin) and lifestyle modification both improved glycemic control. Although the glycemic control by oral hypoglycemic was more significant. Conclusion: Lifestyle modification and oral hypoglycemic both are highly beneficial for glycemic control in type 2 diabetes mellitus. Management with OHG along with life style and dietary modifications has greater benefits.