The effects of antibacterial agents on the dental biofilm (experimental study)

The condition of the oral and oropharyngeal cavities is inextricably linked to the general health and well-being of an individual. Colonization by pathogenic microorganisms or an imbalance of the physiological microbiome in the oral cavity can play an essential role in the development of biofilms as well as many common oral and oropharyngeal conditions, as diverse as dental caries, periodontal diseases and diseases gingivitis. The objective of our work was to test the efficacy of Eludril ® and Betadine ® on Streptococcus Mitis by determining their minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) and to evaluate the action of these drugs. Two molecules face bacterial adhesion on dental surfaces as well as on implant surfaces.The results of our study showed an Eludril® MIC of 0.12 μg / ml and a MBC ® with an interval of [0.25-0.125] μg/ml, the MIC of Betadine was 20 μg/ml with a MBC of one interval. of [40-20] μg / ml. Both antiseptics were effective on bacterial adhesion on enamel surfaces as well as on titanium surfaces, the results also showed the importance of surface characteristics and more specifically the influence of surface roughness on bacterial adhesion. To conclude, the use of mouthwashes with Eludril® or Betadine ®has shown an important role in the fight against the formation of biofilms whatever the surface and an optimal microbial activity against S. mitis strains.