Comparative evaluation of clinicophysiological changes after intravenous administration of dexmedetomidine-butorphanol and dexmedetomidine-midazolam as preanaesthetic with propofol anaesthesia in dog

The present study was conducted to compare and evaluate the intravenous dexmedetomidine-butorphanol and dexmedetomidine-midazolam as preanaesthetic with propofol anaesthesia in dog. The study was conducted on 14 (fourteen) clinical cases of canine of either sex, irrespective of age presented to the T.V.C.C., COVAS, Parbhani for various surgical interventions randomly divided into two groups each consisting of seven dogs. All the dogs in study were administered with inj. Atropine sulphate @ 0.04 mg/kg body weight subcutaneously. In group A, after administration of inj. Atropine sulphate, 10 min later combination of Inj. Dexmedetomidine HCL (10 µg/kg body weight) and Inj. Butorphanol tartarate (0.2 mg/kg body weight) mixed in single syringe was administered intravenously whereas in group B, combination of Inj. Dexmedetomidine HCL (10 µg/kg body weight) and Inj. Midazolam maleate (0.2 mg/kg body weight) mixed in single syringe was administered intravenously. Quality of sedation was assessed followed by inj. Propofol was administered till the effect to get the surgical stage of anaesthesia and required amount was calculated as induction dose. Intermittent doses of propofol were given for maintenance of anaesthesia when required. The study was comparatively evaluated on the basis of clinical parameter, evaluation of reflexes and physiological parameters. It was found that all the dogs resumes lateral recumbency immediately after administration of drug combination (DB/DM) in both groups. Evaluation of various reflex revealed profound sedation with excellent jaw relaxation, moderate to completely abolished palpebral and pedal reflex and rostroventral eyeball position making pupil invisible during sedation and anaesthesia. From the present study it was concluded that intravenous administration of dexmedetomidine-butorphanol (DB) and dexmedetomidine-midazolam (DM) as preanaesthetic combinations produced profound sedation, rapid onset of action and excellent degree and depth of analgesia along with muscle relaxation extent of which is comparatively more in group DM than DB. Dexmedetomidine-butorphanol and dexmedetomidine-midazolam with propofol produced better quality and degree of basal an aesthesia for the minor and major surgeries in canine patients.