Ascorbic acid (vit-c) induced biochemical alternation of collagen characteristics in the heart tissues of swiss mice

Collagen is a fibrous structural protein that provide strength to the different tissue of the body. Vitamin C plays an important role in collagen synthesis and stabilization by hydroxylation of the proline residue. As a person ages the quality of the collagen degrades due to the intra molecular and inter molecular cross-linking. In our present study when Swiss a mice were treated with vitamin C a insignificant increase in collagen concentration was found in the heart tissue. Heart contains less quantities of collagen protein when compared with other organs. Earlier workers suggest that the newly synthesized collagen may helpful for enhancing the function of efficiency of the heart. Since heart also response to the vitamin C for collagen synthesis, a required amount of vitamin C intake may help to/forage related heart problems. The values for salt soluble, acid soluble and total collagen content of control and experimental condition are 8.212, 5.852, 23.163, 37.229 and 10.619, 11.142, 31.070, 52.832 respectively. Similarly the values of % of salt solubility, % of acid acid solubility of control and experimental values are 21.798, 15.214 and 20.289, 23.444 respectively. The values of salt soluble / salt insoluble and acid soluble / acid insoluble are 0.290, 0.181 and 0.256, 0.335 respectively. Values are not significant at 0.05 confident levels.