Safety and efficacy of fluoroscopic guided instillation of povidone iodine with contrast agent for treatment of chyluria

Objectives: To evaluate the safety and efficacy of fluoroscopic guided instillation of povidone iodine with contrast agent. To compare the results obtained with that of povidone iodine instillation without using fluoroscopy. Methods: A prospective study was done in Institute of Urology, MMC, Chennai between February 2015 to February 2016. 43 patients were included in the study after conforming chyluria. Patients were randomly divided into 2 groups- Study group including 20 patients and Control group including 23 patients. Study group was treated with fluoroscopic guided instillation of povidone iodine with contrast where as in Control group, fluoroscopy was not used.Single instillation of 10 ml of 0.2% povidone iodine were given in both groups.Post procedure ether test and cystoscopy was done every 3 weeks for a total duration of 3 months. If symptoms of chyluria recurred, instillation was repeated. Results: Majority of participants in study group were affected in right side (55%), while in control group majority were affected in left side (56.5%). This difference was not statistically significant. On comparing frequency of sittings needed, only 15% patients in study group needed more than one sitting versus 56.5% in control group, which was statistically significant. 15 % of patients in study groups experienced any complication versus 13% in control group. The difference was not statistically significant. Conclusion: Use of fluoroscopy guided instillation of povidone iodine is safe and efficacious. Single instillation is as efficacious as multiple instillation regimens.