Prognostic significance of high sensitive–c-reactive protein (HS-CRP) in acute myocardial infarction

Background: Coronary Artery Disease is one of the leading cause of death, ranked “FIRST” worldwide among the eight killer diseases. It accounts for one-third of all deaths worldwide, two thirds of which occur in the developing countries. Elevated levels of hs–CRP found to be associated with deleterious effects on endothelial function and platelets, which increase risk of atherosclerotic plaque formation. Keeping this in view, it is important to assess the global risk of CAD in patients and in asymptomatic individuals, using a combination of clinical assessment and measurement of biomarkers like hs-CRP as inflammatory markers and to correlate them with that of CAD, for early intervention of life saving prophylaxis and as a prognostic marker. Aim and Objectives: To estimate the levels of hs-CRP in diagnosed patients with acute myocardial infarction and to correlate the level of hs-CRP with the outcome of the patient with acute myocardial infarction within (0-7) day. Material and Method: A cross sectional study was conducted on randomly selected patients with clinically diagnosed acute myocardial infection admitted in NSCB Medical College, Jabalpur. After a thorough clinical examination and history taking, the procedure was explained to the subjects. 3ml of venous blood was collected to study the level of hs-CRP in each subject. Method of estimation: hs-CRP was estimated by Quantitative Nephelometric method. Results: There was a male dominant presentation of acute myocardial infarction with sex ratio of 5.6: 1. Maximum presentation of acute MI was between 5th to 6th decade with mean age of 55.33 years. hs-CRP level were significantly high in acute MI patients with more complications like MR, CCF, Arrhythmia, low ejection fraction and increased ST segment elevation. hs-CRP level were significantly high in deranged lipid profile and in increase CPK-MB levels. Conclusion: Acute MI is a devastating global health problem with rising incidence in developing countries like India. In our study, hs-CRP levels are significantly high in short and long term complication of acute MI. Thus, in patient of Acute MI, a low cost simple investigation, hs-CRP can be highly sensitive independent biomarker for acute MI, its complications and severity.